This will be the third meeting this season, and they will also face each other in the League Cup final on 24 February. City won 2-0 in August's Community Shield, while Chelsea were 2-0 victors in December's reverse league fixture
Manchester City have lost 25 Premier League matches versus Chelsea, more than against any other opponent.
Chelsea are the only side to win more than two top-flight fixtures against a team managed by Pep Guardiola.
City have the division's best home record this season, with 12 wins from 13 games.
They could become the first club to score multiple goals in 15 consecutive top-flight home fixtures since Tottenham had a run of 16 in a row from March to December 1965.
Pep Guardiola's side have scored 27 goals in their past five games at the Etihad Stadium in all competitions.
Manchester City have dropped 16 points this season, two more than in the whole of 2017-18.
Three of their four league defeats this season came after they scored the opening goal.
Sergio Aguero has 22 goals in his 15 most recent Premier League starts at home, scoring in each of the last six.
The Blues could equal the club Premier League record of failing to score in three consecutive away fixtures, set from December 1992 to January 1993 and matched in April 2002.
They could lose four successive away matches in all competitions for the first time since a run of five in a row from January to March last year.
Their most recent away goal was N'Golo Kante's 51st-minute winner at Crystal Palace on 30 December - 309 minutes ago.
Chelsea are winless in six Premier League away fixtures against established top-six rivals, losing each of the last four.
Gonzalo Higuain has scored 38 goals in 37 league appearances under Maurizio Sarri.
In the words of my Old Man, "Life will never be the same without Man City, so get it in while you can".
The Future's Bright, The Future's Blue!!!